Dr. Steffen Kaiser

Teaching Assistant and Head of Mass Spectrometry Service

Tasks since April 2021:

– Head of Mass spectrometry Service Unit

– Head of 4th Semester Practical Course Instrumental Analysis (Pharmacy State Exam)

Research interest:

– Undiscovered targets of RNA methyltransferases

– Nucleoside analytics using modern mass spectrometry techniques

Publications:

Kaiser S, Byrne SR, Ammann G, Asadi Atoi P, Borland K, Brecheisen R, DeMott MS, Gehrke T, Hagelskamp F, Heiss M, Yoluc Y, Liu L, Zhang Q, Dedon PC, Cao B, Kellner S. Strategies to avoid artifacts in mass spectrometry-based epitranscriptome analyses. Angew Chem Int Ed Engl.

– Ignatova, V. V., S. Kaiser, J. S. Y. Ho, X. Bing, P. Stolz, Y. X. Tan, C. L. Lee, F. P. H. Gay, P. R. Lastres, R. Gerlini, B. Rathkolb, A. Aguilar-Pimentel, A. Sanz-Moreno, T. Klein-Rodewald, J. Calzada-Wack, E. Ibragimov, M. Valenta, S. Lukauskas, A. Pavesi, S. Marschall, S. Leuchtenberger, H. Fuchs, V. Gailus-Durner, M. H. de Angelis, S. Bultmann, O. J. Rando, E. Guccione, S. M. Kellner and R. Schneider , The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programmes, Genes & Development.

– Ignatova, V. V., S. Kaiser, J. S. Y. Ho, X. Bing, P. Stolz, Y. X. Tan, C. L. Lee, F. P. H. Gay, P. R. Lastres, R. Gerlini, B. Rathkolb, A. Aguilar-Pimentel, A. Sanz-Moreno, T. Klein-Rodewald, J. Calzada-Wack, E. Ibragimov, M. Valenta, S. Lukauskas, A. Pavesi, S. Marschall, S. Leuchtenberger, H. Fuchs, V. Gailus-Durner, M. H. de Angelis, S. Bultmann, O. J. Rando, E. Guccione, S. M. Kellner and R. Schneider, METTL6 is a tRNA m(3)C methyltransferase that regulates pluripotency and tumor cell growth, Science Advances

– Drino, A., Oberbauer, V., Troger, C., Janisiw, E., Anrather, D., Hartl, M., Kaiser, S., Kellner, S. and Schaefer, M. (2020) Production and Purification of Endogenously Modified tRNA-Derived Small RNAs. RNA Biology. PMID: 32138588

– Meyer, B., Immer, C., Kaiser, S., Sharma, S., Yang, J., Watzinger, P., Weiss, L., Kotter, A., Helm, M., Seitz, H.M. et al. (2019) Identification of the 3-amino-3-carboxypropyl (acp) transferase enzyme responsible for acp3U formation at position 47 in Escherichia coli tRNAs. Nucleic Acids Res. PMID: 31863583

– Reichle VF, Kaiser S, Heiss M, Hagelskamp F, Borland K, Kellner S. (2018) Surpassing limits of static RNA modification analysis with dynamic NAIL-MS, Methods, PMID: 30395967