Nature Communications PMID: 36631525
2023
RSC Chemical Biology PMID: 37181633
Temporal resolution of NAIL-MS of tRNA, rRNA and Poly-A RNA is overcome by actinomycin D
Plant Commun. PMID: 37287225
The plant cytosolic m6A RNA methylome stabilizes photosynthesis in the cold
Pharmakon
Das Mikrobiom im Wechselspiel mit Nukleinsäure-Modifikationen
Nucleic Acids Research PMID: 37650648
Different modification pathways for m1A58 incorporation in yeast elongator and initiator tRNAs
Biochim Biophys Acta Mol Basis Dis . PMID: 37640114
Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis
Antiviral Res . PMID: 37690700
Sangivamycin is preferentially incorporated into viral RNA by the SARS-CoV-2 polymerase
Acc Chem Res. PMID: 37944919
Pitfalls in RNA Modification Quantification Using Nucleoside Mass Spectrometry
ACS Chem Biol. PMID: 37962075
Experience with German Research Consortia in the Field of Chemical Biology of Native Nucleic Acid Modifications
2022
Front Cell Dev Biol. PMCID: PMC9125315
Editorial: Viruses and Epitranscriptomes: Regulation of Infection and Antiviral Response.
ChemBioChem https://doi.org/10.1002/cbic.202200270
Opportunities and challenges to profile mRNA modifications in Escherichia coli
Clin Epigenetics . PMID: 36089606
Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell line
Nat Immunol . PMID: 35879451
The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells
2021
Nature Communications PMID: 33452242
Cell culture NAIL-MS allows insight into human tRNA and rRNA modification dynamics in vivo.
Methods Mol Biol. PMID: 34085252
Quantification of Modified Nucleosides in the Context of NAIL-MS.
Genes (Basel) PMID: 34573326
The Stress-Dependent Dynamics of S. cerevisiae tRNA and rRNA Modification Profiles.
Angew Chem Int Ed Engl. PMID: 34339593
Strategies to avoid artifacts in mass spectrometry-based epitranscriptome analyses.
Methods Enzymol. PMID: 34517944
Analysis of the epitranscriptome with ion-pairing reagent free oligonucleotide mass spectrometry.
Int J Mol Sci. PMID: 33799331
m5U54 tRNA Hypomodification by Lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAs.
2020
Science advances PMID: 32923617
METTL6 is a tRNA m(3)C methyltransferase that regulates pluripotency and tumor cell growth.
Nucleic Acids Research PMID: 33330931
Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6.
RNA Biology PMID: 32138588
Production and Purification of Endogenously Modified tRNA-Derived Small RNAs
Nucleic Acids Research PMID: 32083657
Broadly applicable oligonucleotide mass spectrometry for the analysis of RNA writers and erasers in vitro
Genes Dev PMID: 32217665
The rRNA m(6)A methyltransferase METTL5 is involved in pluripotency and developmental programs
Angew Chem Int Ed Engl PMID: 32160400
Synthesis of Galactosyl-Queuosine and Distribution of Hypermodified Q-Nucleosides in Mouse Tissues
ChemBioChem PMID: 32394608
Synthesis and Metabolic Fate of 4-Methylthiouridine in Bacterial tRNA
Nucleic Acids Res (2020)
Eukaryotic life without tQCUG: the role of Elongator-dependent tRNA modifications in Dictyosteliumdiscoideum
RNA doi:10.1261/rna.076380.120 PMID: 32763916
Identification and rescue of a tRNA wobble inosine deficiency causing intellectual disability disorder
RNA Biology (2020)
tRNA-modifying enzyme mutations induce codon-specific mistranslation and protein aggregation in yeast
Angew Chem Int Ed Engl (2020)
Chemical amination/imination of carbonothiolated nucleosides during RNA hydrolysis
2019
Nature Protocols PMID: 30559375
Isotope-dilution mass spectrometry for exact quantification of noncanonical DNA nucleosides
Genes (Basel) 10. PMID: 30621251
Production and Application of Stable Isotope-Labeled Internal Standards for RNA Modification Analysis.
Biol Chem. PMID: 30893050
Benefits of stable isotope labeling in RNA analysis
PLoS Biol 17, e3000297. PMID: 31199786
Cytosine-5 RNA methylation links protein synthesis to cell metabolism
Mol Cell Biol. PMID: 31263000
Formation of tRNA wobble inosine in humans is disrupted by a millennia-old mutation causing intellectual disability
Nat Commun 10, 3373. PMID: 31358763
Time-resolved NMR monitoring of tRNA maturation
Nucleic Acids Res. PMID: 31863583
Identification of the 3-amino-3-carboxypropyl (acp) transferase enzyme responsible for acp3U formation at position 47 in Escherichia coli tRNAs
Nature Communications PMID: 31811240
NAIL-MS reveals the repair of 2-methylthiocytidine by AlkB in E. coli
2018
Methods PMID: 30395967
Surpassing limits of static RNA modification analysis with dynamic NAIL-MS
ChemBioChem PMID: 30328661
NAIL-MS in E. coli determines the source and fate of methylation in tRNA
2017
RNA Biol. 2017 May 10:0. doi: 10.1080/15476286.2017.1325063.
Observing the fate of tRNA and its modifications by nucleic acid isotope labeling mass spectrometry: NAIL-MS
Mol Cell Biol. doi: 10.1128/MCB.00214-17. PubMed PMID: 28784718.
TRMT1-catalyzed tRNA modifications are required for redox homeostasis to ensure proper cellular proliferation and oxidative stress survival.
Nature Chemical Biology PMID: 28604692
Oxidation of labile phosphorothioate DNA modifications leads to lethal genomic instability
2016
Proc Natl Acad Sci U S A 2016
Novel genomic island modifies DNA with 7-deazaguanine derivatives
RNA Biol 1-11. doi:10.1080/15476286.2016.1236170
The RNA methyltransferase Dnmt2 methylates DNA in the structural context of a tRNA
RNA Biol 2016 Nov 30:1-9. doi: 10.1080/15476286.2016.1261788.
Detection of nucleic acid modifications by chemical reagents
2015
PLoS One 2015. 10(7): p. e0133321.
Eukaryotic rRNA Modification by Yeast 5-Methylcytosine-Methyltransferases and Human Proliferation-Associated Antigen p120
Methods Enzymol 2015. 560: p. 29-71.
A Platform for Discovery and Quantification of Modified Ribonucleosides in RNA: Application to Stress-Induced Reprogramming of tRNA Modifications
RNA 2015. 21(12): p. 2103-18.
An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis
RNA Biol 2015. 12(10): p. 1152-8.
Variable presence of 5-methylcytosine in commercial RNA and DNA
2014
EMBO J 2014. 33(18): p. 2020-39.
Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders
PLoS One 2014. 9(2): p. e89640.
Partial methylation at Am100 in 18S rRNA of baker’s yeast reveals ribosome heterogeneity on the level of eukaryotic rRNA modification
Chem Commun (Camb) 2014. 50(26): p. 3516-8.
Profiling of RNA modifications by multiplexed stable isotope labelling
Nucleic Acids Res 2014. 42(18): p. e142.
Absolute and relative quantification of RNA modifications via biosynthetic isotopomers
Nucleic Acids Res 2014. 42(20): p. 12735-45.
Dye label interference with RNA modification reveals 5-fluorouridine as non-covalent inhibitor
2013
PLoS One 2013. 8(7): p. e67945.
Structure-function relationship of substituted bromomethylcoumarins in nucleoside specificity of RNA alkylation
2012
Nucleic Acids Res 2012. 40(12): p. 5523-34.
Related haloarchaeal pleomorphic viruses contain different genome types
Nat Struct Mol Biol 2012. 19(9): p. 900-5.
RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis
2011
Nucleic Acids Res 2011. 39(16): p. 7348-60.
A multifunctional bioconjugate module for versatile photoaffinity labeling and click chemistry of RNA
2007
RNA Biol, 2010. 7(2): p. 237-47