The role of RNA modifications in neurological diseases
tRNAs are the most intensively modified RNAs with up to 16 modified residues (around 20% of the complete tRNA). Although the dynamic nature of tRNA modifications is crucial to cell survival, Loss or creation of certain RNA modifications are involved in cancer, neuronal diseases and mitochondrial diseases.
Collaborators: Dr. Alex Vicente, Gregor Ammann, Max Berg, Hagen Wesseling, Matthias Brandl